Marvel Nemesis: The Imperfects (2005) #1

"The Rise of the Imperfects" An evil scientist sets his crosshairs on planet Earth, in search of test subjects for his experiments, transforming even the most timid creatures into vicious fighting machines. Thousands of years later, the Thing, Wolverine, Spider-Man and Elektra all find themselves unwilling participants in the scientist's millennia-old trials...or perhaps not all of them are that unwilling.