Iron Man: The End (2008) #1

It's the middle decades of the 21st century. After a lifetime fighting crime, corporate evil and super-powered villainy as Iron Man, industrialist and inventor Tony Stark faces his biggest challenge ever: building the legacy he will leave humankind after he's gone. But when his world-changing project comes under attack, Tony must fight espionage and super-villainy once more, perhaps for the final time.