The Amazing Spider-Man (1963) #217

Hydro-man is revealed to be behind Barney Wicker's assassination attempt; good thing Spider-Man got to Wicker in time! Sandman makes moves on Hydro-man's bar babe girlfriend, Sadie Frickett, leading to a super-powered bar brawl! The three reconcile, (both men decide to share Sadie), and tear up New York with a crime spree! Spider-Man's taking it to the docks, to take out his two most ferocious foes.